Cd8 positive lymphomatoid papulosis

2020-01-18 18:33

Lymphomatoid papulosis type D: a newly described variant easily confused with cutaneous aggressive CD8positive cytotoxic Tcell lymphoma. Cardoso J(1), Duhra P, Thway Y, Calonje E. Author information: (1)Dermatopathology Department, St. John's Institute of Dermatology, London, UK. Lymphomatoid papulosis (LyP) is defined as a chronic recurrentLymphomatoid papulosis (LyP) is a cutaneous CD30positive Tcell lymphoproliferative disorder that occurs primarily in adults and presents with crops of papules that become necrotic and cd8 positive lymphomatoid papulosis

Immunophenotyping studies of the lymphomatoid papulosis lesions have shown a predominance of a CD4 expression and negativity for CD8. However, a positive CD8 expression has rarely been reported for LyP. Herein we report on a case of CD8 positive lymphomatoid papulosis in a 43yearold man.

LyP is a chronic, self healing skin disease composed of large, atypical, anaplastic, immunoblastic or Hodgkinlike cells in a marked inflammatory background (WHO 2008) INTRODUCTION. Lymphomatoid papulosis (LyP) is a recurrent, selfhealing papulonodular skin eruption with histologic features of a CD30 lymphoid proliferation of atypical T cells [. LyP is part of the group of cutaneous CD30 lymphoproliferative disorders (LPDs) that includes primary cutaneous anaplastic large cell lymphoma (PCALCL) and borderline CD30 lesions. cd8 positive lymphomatoid papulosis The differential diagnosis of CD8positive (type D) lymphomatoid papulosis Seventeen cases were classified as lymphomatoid papulosis (LyP) type D, eight as cutaneous anaplastic large cell lymphoma (CALCL) and two as CD8 mycosis fungoides (MF) with CD30 expression.

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